The document is a comprehensive chronological log of significant U.S. federal regulatory, policy, and guidance actions pertinent to research administration, compliance, and oversight, maintained as of December 31, 2024. Covering a broad spectrum of agencies—including NIH, NSF, DOE, DARPA, OSTP, NIST, HHS, FDA, and others—the entries detail developments ranging from research security and risk-based review processes, data management and sharing policies, and implementation of regulations for controlled unclassified information, to updates in human subjects research protection, scientific integrity, cybersecurity, and export controls. The document includes links to source materials for each action, as well as brief contextual notes regarding implementation or agency-specific considerations.
Key regulatory topics recurring throughout the document include: oversight and management of sensitive or dual-use research (e.g., DURC, PEPP); evolving cybersecurity and research security frameworks; compliance with data privacy and sharing requirements (such as HIPAA and the Genomic Data Sharing Policy); workforce and equity regulations; guidance on grant and financial management; and the modernization of compliance infrastructure (e.g., transitioning to new reporting systems and stricter disclosure requirements). The compilation reflects an increased emphasis in recent years on safeguarding research from foreign interference and promoting scientific integrity, transparency, and inclusivity. The historical scope—from the 1990s through 2024—demonstrates the cumulative layering of compliance obligations, highlighting both the continuity and evolution of federal expectations in support of the responsible conduct of science and research.
