The September 2025 COGR Update provides an overview of recent federal developments affecting U.S. research institutions, including proposed regulatory changes, executive orders, litigation updates, and agency-specific policy shifts impacting research funding, compliance, security, and administration. Key topics include the release of the NASEM report on streamlined research regulations, forthcoming changes to federal indirect cost (F&A) reimbursement, enhanced research security and reporting requirements (notably from NIH and DOD), administrative actions concerning research funding priorities, and ongoing responses to executive orders affecting grantmaking, DEI policies, and artificial intelligence. The update highlights COGR’s continued advocacy, resource development, and member engagement efforts to address these evolving federal policies and support institutional compliance and research competitiveness.