The November 2025 COGR Update details the resumption of federal research operations following a prolonged government shutdown, highlights key policy initiatives including significant deregulatory actions (OMB Memo M-25-36) and upcoming changes to federal research compliance and funding structures, and introduces new resources such as a redesigned COGR website and practical guidance for technology transfer offices. The document summarizes ongoing regulatory, legal, and compliance developments—ranging from adjustments in NIH and DOE cost reimbursement policies, new biosafety and research security requirements, to significant court cases affecting research funding—and shares insights from recent COGR membership discussions on financial sustainability, administrative challenges, and the future of federal research support. Overall, the update serves as both a resource compendium and an advocacy platform for research institutions navigating evolving federal regulations and funding landscapes.